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AZD 5991

CAS No. 2143061-81-6

AZD 5991 ( AZD5991 )

Catalog No. M13426 CAS No. 2143061-81-6

AZD 5991 (AZD5991) is a potent and selective macrocyclic inhibitor of Mcl-1 with sub-nanomolar affinity.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    AZD 5991
  • Note
    Research use only, not for human use.
  • Brief Description
    AZD 5991 (AZD5991) is a potent and selective macrocyclic inhibitor of Mcl-1 with sub-nanomolar affinity.
  • Description
    AZD 5991 (AZD5991) is a potent and selective macrocyclic inhibitor of Mcl-1 with sub-nanomolar affinity; promotes rapid apoptosis in Mcl-1-dependent cell lines (GI50=10 nM in multiple myeloma cell lines), disrupts Mcl-1/Bak complex; completely causes tumor regression in several mouse xenograft models after a single tolerated dose.Blood Cancer Phase 1 Clinical
  • Synonyms
    AZD5991
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    Bcl-2
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    2143061-81-6
  • Formula Weight
    672.26
  • Molecular Formula
    C35H34ClN5O3S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 41.67 mg/mL 61.98 mM; H2O : < 0.1 mg/mL
  • SMILES
    CC1=C2C(=NN1C)CSCC3=NN(C(=C3)CSC4=CC5=CC=CC=C5C(=C4)OCCCC6=C(N(C7=C6C=CC(=C27)Cl)C)C(=O)O)C
  • Chemical Name
    (Z)-16-chloro-11,21,25,61-tetramethyl-11H,21H,61H-10-oxa-4,8-dithia-1(7,3)-indola-2(4,3),6(3,5)-dipyrazola-9(3,1)-naphthalenacyclotridecaphane-12-carboxylic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Alexander W. Hird, et al. Abstract DDT01-02: AZD5991: A potent and selective macrocyclic inhibitor of Mcl-1 for treatment of hematologic cancers, AACR. DOI: 10.1158/1538-7445.
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